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High-Throughput Screening (HTS)

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By: DAVID SAVASTANO

Contributing Editor, Coatings World and Ink World, Coatings World and Ink World Magazine

A process in which batches of compounds are tested for binding activity or biological activity against target molecules. High-throughput screening seeks to evaluate large numbers of compounds rapidly and in parallel. Compounds are tested as inhibitors of target enzymes, as competitors for binding of a natural ligand to its receptor, and as agonists or antagonists for receptor-mediated intracellular processes.

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